Intranasal immunotherapy is more effective than intradermal immunotherapy for the induction of airway allergen tolerance in Th2-sensitized mice.

Th2-Sensitized Mice Induction of Airway Allergen Tolerance in Than Intradermal Immunotherapy for the Intranasal Immunotherapy Is More Effective

Lung-derived innate cytokines: new epigenetic targets of allergen-specific sublingual immunotherapy

Objective(s):Sublingual allergen-specific immunotherapy is a safe and effective method for treatment of IgE-mediated respiratory allergies; however, the underlying mechanisms are not fully understood. This study was planned to test whether sublingual immunotherapy (SLIT) can exert epigenetic mechanisms through which the airway allergic responses can be extinguished. Materials and Methods:BALB/c...

Immunotherapy of Chenopodium Album Induced Asthma by Intranasal Administration of CpG Oligodeoxynucleotides in BALB/c Mice

Background: There are many therapeutic methods for allergic conditions. CpG oli-gonucleotides play a critical role in immunity via the augmentation of Th1 and suppres-sion of Th2 responses. Objective: In the present study we aimed to estimate the effec-tiveness of intranasal administration of CpG ODN plus Chenopodium album allergen in allergic asthma compared with the administration of allergen...

Allergen-encoding bone marrow transfer inactivates allergic T cell responses, alleviating airway inflammation.

Memory Th2 cell responses underlie the development and perpetuation of allergic diseases. Because these states result from immune dysregulation, established Th2 cell responses represent a significant challenge for conventional immunotherapies. New approaches that overcome the detrimental effects of immune dysregulation are required. We tested whether memory Th2 cell responses were silenced usin...

Transcutaneous immunotherapy via laser-generated micropores efficiently alleviates allergic asthma in Phl p 5–sensitized mice

BACKGROUND Specific immunotherapy via the subcutaneous or oral route is associated with local and, in some cases, systemic side effects and suffers from low patient compliance. Due to its unique immunological features, the skin represents a promising target tissue for effective and painless treatment of type I allergy. The current study was performed to compare the efficacy of transcutaneous im...